CORE TECHNOLOGY

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R&D
R&D CORE TECHNOLOGY
CORE TECHNOLOGY

OHPASTM Linker (Ortho-Hydroxy Protected Aryl Sulfate)

IntoCell has developed a novel self-immolative group (SIG), dubbed OHPASTM (Ortho-Hydroxy Protected Aryl Sulfate). OHPASTM has a highly flexible cleavage chemistry that works effectively with a wide variety of phenolic and non-phenolic payloads. It is also designed to incorporate a wide variety of functional groups for linking targeting moieties, as well as with a range of differing triggering groups.

OHPASTM Linker-Toxin Library

IntoCell possesses a OHPASTM Linker-toxin Library covering a variety of toxins with different mechanisms of action. It has an optimized linker-toxin library for fast delivery of a pre-clinical candidate in novel ADC programs.


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